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8 Posts

nadiabarati

04/28/06 - 10:38 AM

Which modification of an endogenous pharmacological active peptide would be most likely to slow the metabolism of the peptide,thus decreasing its clearence and increasing its half-life ?? a-administering the peptide with an enteric coating
b.-Decreasing the number of amino acids in the peptide
c.-Ensuring a free amino group at the N terminal
d.-Ensuring a free carboxyl group at the C terminal
e.-Substituting a D for an L amino acid

lalitha
Forum Junior

Topics: 9
Posts: 51

04/29/06 - 11:21 AM

is it A?

disha
Forum Senior

Topics: 5
Posts: 118

04/29/06 - 01:24 PM

is it c?that would dicrease its clearance?

ramo7
Forum Senior

Topics: 15
Posts: 126

04/30/06 - 02:35 AM

i think its d? making it more negative thereby less likely to be filtered and excreted...???

disha
Forum Senior

Topics: 5
Posts: 118

04/30/06 - 07:51 AM

ya ramo,ur right.it should be d

drbin
Forum Guru
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Topics: 27
Posts: 535

05/01/06 - 10:53 PM

d?

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dariush
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Topics: 20
Posts: 356

05/11/06 - 01:01 PM

why?

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doctoraj10
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Topics: 2
Posts: 3

05/11/06 - 01:12 PM

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