ladybug
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A neoplasm in the colon invades thru the basement membrane thru the lamina propria. Which of the following proteins will likely be involved in invasion.
a. APC
b. p53
c. ras
d. Rb
e. Type IC collagenase
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| robin082006
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A
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| r_albayunen
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A
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| r_albayunen
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hmm what about ras?
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| krsna
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i think the ques asks the reason for the invasion....why not E?
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| dariush
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i think krsna is making a point:
the deletion of a healthy copy of the APC (adenomatous polyposis coli) gene on chromosome 5 leaving behind a mutant copy of this tumor suppressor gene
Two results:
One of the functions of the APC gene product is to destroy the transcription factor β-catenin thus preventing it from turning on genes that cause the cell to divide . With no, or a defective, APC protein, the normal brakes on cell division are lifted. Another function of the APC protein is to help attach the microtubules of the mitotic spindle to the kinetochores of the chromosomes. With no, or a defective, APC product available, chromosomes are lost from the spindle producing aneuploid progeny.
http://users.rcn.com/jkimball.ma.ultranet/Biology...
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| kumar81
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E looks like a coorect answer (given in FA), they r asking abt invasion not how tumor goes from benign to malignant
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| mjl1717
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i would have said answer -e since we're talking of type IV collagen.
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| mohelgamal
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the question says directly involved in invasion
so i think its e
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| proctalgia
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 proteins will likely be involved in invasion--->collagenase
I go with EEEEE
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| doc179
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E
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| Allison
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e. Type IC collagenase
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