robin082006
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402. Gardner's syndrome is an autosomal dominant condition characterized by multiple polyps of the intestines, bony tumors, skin cysts, and a high risk of intestinal cancer. A family is encountered in which a greatgrandfather,grandmother, and father are affected with Gardner's syndrome and develop intestinal cancer in their thirties. The father brags that none of his four children have inherited Gardner's syndrome because they lack skin cysts and have not had cancer. The chance that at least one child has inherited the Gardner's syndrome allele, and the reason the children have not manifested cancer, are
a. 1/4, ascertainment bias
b. 1/2, variable cancer predisposition
c. 3/4, early-onset disease manifestation
d. 13/16, incomplete medical evaluation
e. 15/16, later-onset disease manifestation
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| ralux
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b
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| robin082006
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try again
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| vanshita
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A?
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| robin082006
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answer is E
all children have no disease=1/2*1/2*1/2*1/2=1/16
At least one child has disease=1-1/16=15/16
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| robin082006
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answer is E
all children have no disease=1/2*1/2*1/2*1/2=1/16
At least one child has disease=1-1/16=15/16
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| Rana Khan
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e
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| sridevibandaru24
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Robin! i am unable to understand the concept. i do not understand why u multiplied1/2*1/2*1/2*1/2. how u got 1/2 for each person? please explain.
thanks
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| robin082006
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Yes, each child has 1/2 chance to be free of disease and 1/2 chance to have disease.
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| Cedrick
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Good math
good question too
Thanks
15/16 later onset disease manifestation
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| vallia
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yes, good calculation, 4 generations, autosomal dominant condition
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