tolito
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the fasting body can make glucose from all the following except
1. arginine
2. methionine
3. propionyacid
4. leucine
5. malate
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| paba
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? Arginine
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| Janka
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lysine and leucine -> the only two KETOgenic amino acids.
-> ans4
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| tolito
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 leucine is not a glucogenic amino acid. same as lysine. the only 2 aa's that are not glucogenic.
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| rouadefoc
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Nice Q
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| danieel
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well detailed and tedious but really relaible answer
from Lehninger Principle of Biochemistry chapter 20 table 20-3:
Glucogenic Amino Acid, Grouped by Site of Entry
PYRUVATE:
Alanine,
Cysteine
Glycine
Serine
Tryptophane(also Ketogenic)
alpha-Ketoglutatate=
Alanine
Glutamate
Glutamine
Histidine
Proline
SUCCINYL-COA
Isoleucine(also ketogenic)
Methionine
Threonine
Valine
FUMARATE:
PHenylalanine(also ketogenic)
Tyrosine(also ketogenic)
OXALOACETATE:
Asparagine
Aspartate
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malate is an intermediate from pyruvate to phosphoenolpyruvate (PEP) pathway and
accually PEP finally via a lot reactions became Glucose-6-phosphate and glucose,
so malate also belongs to glucogenesis pathway ,its difference to ,for example, alanine is that it is some steps further
so the only that remains Propionyacide
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| robin082006
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Hi Danieel,
Propionyl Coa is an intermediate of lipid metabolic pathway that can be used for gluconeogenesis.
I saw a q asking about this.
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| tolito
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yes, odd chain fatty acid can be used for gluconeog thro propionyl coa while even number FA are not gluconeogenic. the propionyl coa is converted to suc co a in 2 steps: prop coa to methylmalonic acid (enz prop coa carboxylase), mma to suc coa (enz meth mal coa mutase). then fumarate, malate then gluconeog pathway. pretty cumbersome. so this is not a preferred route!!
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| 26malik
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good Q . and vgood explainations
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