ralux
Forum Senior
Topics: 5
Posts: 59
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Cortisol has all of the following except:
1, decreasing the sythesis of gluconeogenic enzymes in liver
2, decrease the uptake of AA by muscle
3, decrease the uptake of glucose by muscle
4, increase liver glycogen synthesis
5, increase the output of glucose by liver
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| doc179
Forum Guru
Topics: 66
Posts: 1,210
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1
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| ralux
Forum Senior
Topics: 5
Posts: 59
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can you pls explain why.I was thinking of 4...
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| doc179
Forum Guru
Topics: 66
Posts: 1,210
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you are right thats confusing. what I think is cortisol increase glucose by increasing gluconeogenesis and not by glycogenolysis and so if its not breaking down glycogen , then its increase glycogen in liver...
its just my guess. I chose 1 cos I was sure that it would never decrease the synthesis of gluconeogenic enzymes , if it did then it can not be useful in stress.
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| star1
Forum Guru
Topics: 93
Posts: 827
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Correct answer is 1.
Now about 4 .increase liver glycogen synthesis. this is not correct because remember Cortisol has permisive action with Glucagon and we know that Glucagon increases Liver Glycogenolysis. What U think?
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| doc179
Forum Guru
Topics: 66
Posts: 1,210
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well the Q says " EXCEPT " so are there 2 answers? you are right I do remember its permissive actions with glucagon and epinephrine
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| doc179
Forum Guru
Topics: 66
Posts: 1,210
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but its like glucagon is doing all the glycogenolysis not cortisol , its just allowing glucagon to do its job. well to be frank I do not know why 4 is not the ans to this Q...sorry.
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| star1
Forum Guru
Topics: 93
Posts: 827
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Cortisol has all of the following except.
1-decreasing the sythesis of gluconeogenic enzymes in liver ( Cortisol induce PEPCK an enzyme in Gluconeogenesis 0.
2-decrease the uptake of AA by muscle (Cortisol promote degredation of Protein and delivery of aa)
3-decrease the uptake of glucose by muscle ( Cortisol is Glucogenis and so it decrease Glucose uptake by muscle)
4- increase liver glycogen synthesis (How????
5- increase the output of glucose by liver ( Permissive action with Glucagon)
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| waqastariq
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I think its 1 and what I think is the reason is that:
when the gluconeogenesis enzymes are induced....the other glycolysis enzymes are reduced which causes the cycles to divert to glycogenesis cycle...got it?
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| zenith
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The correct answer definitiely is 1, because cortisol increases hepatic output of glucose via gluconeogenesis.
Since the Qs says "Cortisol has all the following EXCEPT" - the correct choice would be 1. It has all the other actions from 2 to 5.
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| robin082006
Forum Hero
Topics: 471
Posts: 5,119
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I see 4 is the answer, 4 is the action of insulin, not cortisol
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| yasmeen
Forum Guru
Topics: 67
Posts: 935
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cortisol doesn,t cause glycogen synthesis both 1 and 4 r wrong
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| new_n_lost
Politically InCorrect
Topics: 644
Posts: 5,920
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ok the link is up
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| justin425
Forum Newbie
Topics: 1
Posts: 6
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cortisol increases blood glucose by 2 mechanisms: preventing uptake of glucose into many tissues so it can be utilized by the brain, and by increasing gluconeogenisis. and yes it leads to glycogenolysis secondarily by permissive action to glucogon and catecholamines, but for some reason it actually DOES increase glycogen synthesis DIRECTLY by activating glycogen synthase. not really sure why this happens, but they've known about this since the 60's (http://www.sciencemag.org/cgi/content/abstract/14...), and there have been many studies since showing this correlation. I'm not really sure why this happens, but I guess we should know that it does. ANY OTHER THOUGHTS???
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| spinal shock
Forum Junior
Topics: 7
Posts: 63
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both 1 and 4 are wrong
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| Eagle_303
Forum Junior
Topics: 7
Posts: 38
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Dear Brothers/sisters
Cortisole does cause Glycogen synthesis Ref is Guyton's physiology
In fact this is an indirect action
In the liver it enhances the Gluconeogenesis so some glucose is converted into Glycogen
As far as Glycongenolytic action is concerned ,this is its PERMISSIVE ACTION not the individual one.
which means
If Cortisole is given to the animal without glucagone or epipnephrine then no glycogenolytic action
If cortisole is given in the presence of glucagon or epinphrine ,then glycogenolytic action would be much more than if glucagon or epinephrin is given ALONE
Best of luck
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