pearljam59
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The initial vaccines against Haemophilus influenzae type B prepared with capsular polysaccharides were not very effective in children less than 2 years old. Subsequent vaccines have been greatly improved by the conjugation of the capsular polysaccharides to one of several proteins. Why does this conjugation improve immunogenicity?
A) CD4+ T lymphocytes are activated
B) Cytotoxic T lymphocyte responses are increased
C) Direct activation of B lymphocytes by the vaccine is increased
D) Nonimmune clearance of the vaccine is decreased
E) Phagocytosis of the vaccine is increased
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| robin082006
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A
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| r_albayunen
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A
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| Cedrick
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A
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| study_ing
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A
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| rn
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can anyone plz give a brief explanation
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| Musuq
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A) CD4+ T lymphocytes are activated
A peptide is necessary for the APC (macrophage, LB, etc) to process and present the antigenic peptide on its grrove of MHC II to the THo (CD4+) so this THo can switch to TH2 and thus stimulate the B lymphocyte to produce Ab. that's why the polysacharide work better if a protein is added.
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| klimt
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agree A
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| ManuNastai
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http://www.prep4usmle.com/forum/thread/41109
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