pearljam59
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Which of the following modifications of an endogenous pharmacologically active peptide would be most likely to slow the metabolism of the peptide, thus decreasing its clearance and increasing its half-life?
A ) Administering the peptide with an enteric coating
B ) Decreasing the number of amino acids in the peptide
C ) Ensuring a free amino group at the N terminal
D ) Ensuring a free carboxyl group at the C terminal
E ) Substituting a D for an L amino acid
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| gogetit
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its E
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| humpf!!
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is this E? I was thinking A...can anyone explain please?
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| mjl1717
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answer-a-cant explain
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| robin082006
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I GO WITH E
HERE IS MY REASONING
A cannot be the correct answer because it only affects the bioavailability of drug, NOT THE half life and clearance.
B ) Decreasing the number of amino acids in the peptide --> wrong because it increases clearance and half life
C ) Ensuring a free amino group at the N terminal--> affects basophilia or acidophilia of drug--> affects bioavailability
D ) Ensuring a free carboxyl group at the C terminal --> affects the potency of drug
E ) Substituting a D for an L amino acid --> maybe CORRECT ANSWER
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| rman
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Can you explain how the free carboxyl group at the C terminal affects the potency of drug? I agree with E
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| eaguin
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I still think It could be A, when bioavailability goes down, I think that half life will increase, and clearance will decrease. Please can anyone explain this to me?
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| mohelgamal
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No eaguin bioavailability only govern how much of the drug will get to systemic circulation. once in systemic circ the half life of the drug depend on the mechanism the body uses to get rid of it so it has nothing to do with bioavailability . in other world increase clearance decrease half life
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| mohelgamal
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also the body can't utilize d form of any substance but still it looks like the l form (remember d xylose can't be metabolzed in body and exerted as is
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| proctalgia
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Will the substitution of a D for L aa affect the pharmacological activity of the peptide?
 
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| ssrpk
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yes cause tht change in configuration wud not enable the active site of the enzyme to recongnize the susbtrate and the fact tht most of aminoacids we hv are of L config.
answer is E
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| AngelT
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How do you know that stuff????? Is it in kaplan????
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