Machiavelli
Forum Senior
Topics: 49
Posts: 65
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In the First aid it's said that the main determinants for organ rejection are MHCII.
I think it's MHC I.
Is it a mistake ?
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| r_albayunen
Forum Senior
Topics: 0
Posts: 218
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no .. the key here is that when a graft in inserted MHC II on the APC are going to recognized foreign HLA, proteins, antigens of the donors graft right .. these APC are directed to TH CD4 T helper cells to present these foreign proteins (antigens) and that will stimulate proliferation of TH1 cell mediated inmunity specifically CD 8 Cytotoxic MHC I cells that actually are the effector cells that will destroy the graft ..
im sorry im not being so professional .. its just a simple way of describing it .. got it?
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| Machiavelli
Forum Senior
Topics: 49
Posts: 65
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When they say "main determinants for organ rejection" I understans it that MHC II are the important determinants on the organ (the donor) that determine the rejection and not the determinants on the Host that determine the rejection.
Is this my problem ?
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| paganini
Forum Senior
Topics: 26
Posts: 153
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First r_albayune,TH1 and TH2 cells are CD4 not CD8 and MHC II are on APC (antigen presenting cells) so is wrong to say CD8 cytotoxic MHC I cells. What you said was wrong sorry. Both MHC II and MCH I proteins in DONOR cells determine aceptance or rejection, but MHC II proteins play the major role. This is because APCs [either of the graft (the donor) or the recipient] present the foreign proteins (MHC II proteins) to CD4 T cells. This cells, specifically TH1 produce IL-2 that stimulate cytotoxic (CD8+) to form a clone of cells and then do most of the killing recognizing MHC I, but notice that they need to be stimulated by IL-2 produced by CD4 TH1 cells, which need first to bind APCs with MHC II proteins. DIMELO TONIN! 
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