drpkaur
Forum Guru
Topics: 196
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could somebody explain to me the mehanism of action of quinupristin/dalfopristin....in lippincott it says it binds to 50s subunitsforming a stable ternary complex,thus inhibits protein synthesis...wht in kaplan it says something else..plz expalin me in detail..thanx
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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hey guys ,could somebody expalain this to me...
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| tolito
Forum Fanatic
Topics: 119
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am sorry i cannot explain cos i have nto read protein synth in biochem yet but my kaplan 2002 says they act via several mech. one is to bind to the 50s ribos unit and prevent interaction of aminoacyl trna with the acceptor site and stimulate its dissociation from the ternary complex. ssecond they may alos decrease teh release of completed polypeptide by blocking its extrusion.
hope this helps. it is all jargon to me.
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| gpsbrar
Forum Elite
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They are protein inhibitors. They inhibit the A site. The acceptor sitte can not meet the tRNA and thus no synthesis. They are only used if you have Vancomycin resistant staph or Enterococcus.
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