general malaise
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A 70 yr old man died suddenly and unexpectedly. At autopsy, multiple tissue sites were sampled for microscopic analysis. Examination of the tissues showed noncrystalline amorphous deposits of calcium salts in gastric mucosa, renal interstitium, and alveolar walls of lungs. Which of the following conditions is most likely to explain these findings?
A. Chronic hepatitis
B. Chronic glomerulonephritis
C. Disseminated TB
D. Generalized atherosclerosis
E. Normal aging process
F. Pulmonary emphysema
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| robin082006
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E?
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| babli
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D
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| Geroo
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E
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| meroon
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D?
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| general malaise
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answer is B, metastatic calcification secondary to chronic renal disease
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| babli
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how can metastatic calcification/chronic renal disease cause sudden death without any signs & symptoms?general malaise can you explain answer in detail?
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| general malaise
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the explanation given is as follows: microscopic findings suggest metastatic calcification, with deposition of calcium salts in tissues that have physiologic mechanisms for losing acid, creating an internal alkaline environment that favors calcium precipitation. chronic renal disease reduces phosphate excretion by the kidney, resulting in an increase in serum phosphate. because the solubility product of calcium and phosphorus must be maintained, the serum calcium is depressed, triggering increased parathyroid hormone output to increase the calcium level, which promotes calcium deposition.
honestly i still don't understand the mechanism. i only got it right by eliminating answers.
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