mjl1717
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Whats the difference between 0 order 1st order kinetics and give a few examples?
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| Ouli Maty
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Zero order kinetics, the rate of elimination is constant no matter how much the concentration is and if you use a semi-log curve or a normal curve( time vs concentration) , it is going to be a straight line : classical examples Asp high dose, Ethanol...
First order kinetics, the rate of elimination is a function of the concentration at the beginning and, it is an exponential decay curve but in a semi-log, it is a straight line : e.g.most drugs.....
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| mjl1717
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Just to make this a little clearer.
ZERO ORDER
constant amount of x is eliminated per unit time**
If you have 80mg of drug 10 mg is eliminated every 4 hrs
(70 mg is left in 4hrs and so on)
(no fixed half life)( the graph is a straight line decay vs time)
eg.ETOH, phenytoin-high doses,toxic doses of ASA. {rxns reached Vmax]
FIRST ORDER [TYPICAL]
The higher the amt of drug the more rapid the elimination
Constant fraction is eliminated per unit time**
the graph shows an exponential decay vs time
elimination of 50% of drug is called t 1/2
t1/2 =0.7/k k=1st order rate constant of elimination :idea:
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| meg
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thanks to both of you 
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