yasmeen
Forum Guru
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DEFICIENCY OF WHICH OF THE FOLLOWING CAN LEAD TO CLONAL AN ERGY IL-12, IL-10,1L-2 ,IL-6
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| yasmeen
Forum Guru
Topics: 67
Posts: 936
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| r_albayunen
Forum Senior
Topics: 0
Posts: 218
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IL-2?
If there is no IL-2 no prolif of T cells .. no isotype switching for the B cells, bcuz remem that in order for B cells to dif they need Th cells.
Correct me ..
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| tolito
Forum Fanatic
Topics: 119
Posts: 2,170
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yes, my thoughts too. il2 is required with il4 for b cell growth. il4 is the one required for class switch though.
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| tolito
Forum Fanatic
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no, i change my mind. il6 is probably the more appropriate cos it is responsible for bcell differentiation.
il2 is wrong cos we may have T independent antibody production.
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| tolito
Forum Fanatic
Topics: 119
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ok. sorry i have been a blind man leading you all astray.
for certain, it is il 2. failure of its production leads to T Cell clonal anergy. (do not remember the source but this is genuine and not guess work).
il5 is bcel differentiation factor
il 6 is Bcell stim factor ( it stimulates il5)
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| study_ing
Forum Fanatic
Topics: 180
Posts: 2,511
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IL 2
its listed as a cause of SCID in FA
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| StormBlade
Forum Newbie
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Posts: 26
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clonal anergy is caused by the deficiency of costimulation mechanism(b7 and cd28 binding).. and costimulation increases il2 synthesis by 100 times .. so it is IL-2
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