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Kaplan Qbank USMLE



Author8 Posts
  #1

48. Triiodothyronine (T3) is more potent than Thyroxine (T4) for the treatment of hypothyroidism because of which of the following?

A. Active transport into target cells
B. Greater accumulation in the mitochondria
C. Greater receptor affinity
D. Higher oral bioavailability
E. Longer plasma half-life

shocked

  #2

C?

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  #3

C; but not 100% sure. I think higher receptor affinity will lead to increased potency due to more binding.


  #4

Could it be D?


The following is from Harrison online:
T3 is the more potent of the two thyroid hormones, although its circulating plasma level is much lower than that of T4. T3 is less-tightly bound to protein in the plasma than is T4, and so it enters tissues more readily. T3 is three to four times more active than T4 per unit weight, with a half-life of about 1 day, compared to approximately 7 days for T4.


  #5

receptor affinity should be correct. bioavailability is in relation to IV dosing.

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  #6

C for sure...its given in kaplan itself.

  #7

C. last 2 options are for T4.

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B+

  #8

its C
T3 affinity for receptor, T4 for TBG's hence its long half life







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