Do males have a 0% chance of being a CARRIER of an X-linked recessive disease (Duchenne's)?! A man has two brothers who died of Duchenne's so what is the probability that he would be a carrier (he wants to know because he wants to have a baby)?!
funnyhat Forum Newbie
Topics: 0 Posts: 3
06/24/06 - 11:45 PM
#2
Yah, i don't think he's a carrier...unless this is a case of incomplete penetrance. not sure tho
young_doc Forum Guru
Topics: 55 Posts: 732
07/19/06 - 05:47 PM
#3
I think by "carrier" in the case of an X-R disease in males, they just refer to his chances of being affected. Or in other words, his chances of Carrying the affected X! just my guess..
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study_ing Forum Fanatic
Topics: 180 Posts: 2,511
07/20/06 - 10:18 AM
#4
in this guy i think we assume he is asymptomatic despite being old enough...hence the chances of him being a Carrier of the trait are 0. he's a male so he's hemizygous. what thinks the gang?? ___________________ If you yourself are at peace, then there is at least some peace in the world.
tolito Forum Fanatic
Topics: 119 Posts: 2,164
07/20/06 - 02:12 PM
#5
correct. for an x linked recessive gene, a man cannot be a carrier unless the disease does not have complete penetrance. because if the only x he has is diseased, he will hae the disease. ___________________ It has been a looooong hard journey but I am inches away from my destination...
HILFIGER Forum Senior
Topics: 21 Posts: 192
07/21/06 - 11:03 AM
#6
male cannot be a carrier, agree with tolito
macleodkc Forum Newbie
Topics: 0 Posts: 2
07/30/06 - 10:15 AM
#7
Don't want to throw a spanner in the works... all sounds good... but what about penetrance? Can't a male have the X gene but the penetrance be low so it's not expressed?
mjl1717 Forum Hero
Topics: 955 Posts: 5,451
07/30/06 - 04:01 PM
#8
tolito wrote: correct. for an x linked recessive gene, a man cannot be a carrier unless the disease does not have complete penetrance. because if the only x he has is diseased, he will hae the disease.
agree with tolito!
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