robin082006
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447. A young boy is being evaluated for a history of numerous fractures in the past. These fractures have resulted from minimal trauma. Examination of his peripheral blood reveals leukoerythroblastosis with numerous target cells. Which one of the following abnormalities is most characteristic of this boy's disease process?
a. Abnormal "tunneling" of osteoclasts into bone trabeculae
b. Abnormal osteoclasts that lack the normal ruffled border
c. Decreased calcification of osteoid matrix
d. Decreased cartilage cell proliferation at epiphyseal plates of long bones
e. Defective synthesis of type I procollagen
what disease do you think?
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| hrishi
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is it b
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| huzefa
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Osteopetrosis; answer is b.
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| vinaysaini19
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Leukoerythroblastosis is seen in bone marrow replacement anemia. I think it to be thalassemia, just intution. And also I think that explains that this child is having lytic bone lesions due to myeloid metaplasia. I think answer is A
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| robin082006
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answer is B, this q has been discussed.
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| docarchana
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wats the diagonosis..
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| suv
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it is osteopetrosis(marble bone disease)
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| docarchana
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thanx suv..
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