jagian75
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4 drugs produce the same therapeutic effect by the same mechanism but each has a unique toxicity. when used at a max effective therapeutic dos, the drug with which of the foll sets of characteristics is the most likely to have the highest incidence of toxicity?
Median effective dose toxic dose/effective dose99
A 0.5x 2.8
B 1X 2.1
C 5X 4.0
D 33X 3.0
THE ans is B BUT how does one arrive at that?
can anyone clarify?
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| doc179
Forum Guru
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the lower the therapeutic index the higher the toxicity
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| jagian75
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why not A then
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| doc179
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2.1 is lesser than 2.8
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| jagian75
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thanks i thought there should be some relation to the amt of drug taken like 0.5x for 2.8 value
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| doc179
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yeah I know I was also confused when I first came across this Q a weeks ago, but then someone explained to me, said it will be a lot easier if you just consider the therapeutic index...
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| jagian75
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thanks a lot
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| doc179
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you are welcome
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