pearljam59
Forum Guru
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MRL-lpr/lpr mutant mice are useful biomedical research models because of their increased susceptibility to autoimmune disease. These mice are characterized by a defect in the fas gene and a marked increase in T-lymphocyte accumulation as compared with wild-type animals. Based on these characteristics, which of the following is the most likely cause of the increased susceptibility of these mutants to autoimmune disease?
A. Decreased cell-cycle transit time for activated T lymphocytes
B. Decreased dependence on antigen-presenting cells for T-lymphocyte activation
C. Decreased responsiveness to clonal deletion signals in the thymic cortex
D. Increased responsiveness of mature T lymphocytes to antigenic stimulation
E. Increased thymocyte precursor proliferation in the bone marrow
F. Increased thymocyte proliferation rate in the thymic cortex
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| robin082006
Forum Hero
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C
Just guess the answwer
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| jagian75
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in kaplan in immunology section there is this topic on the positive selection and the negative selection so if the t cell responds more strongly it has the propensity to dev into auto immunity so by decreasing the response to the such clonal deletion in the thymic cortex one can inc the susceptibility to the autoimmune disease. so i go for C
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