giovanni83
Forum Senior
Topics: 24
Posts: 125
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Hi guys...I don't understand:
I know that insulin is an hormones that plays a role in the well-fed state: it promotes GLICOGEN SINTHESYS.
But I read that insulin also activates PFK-1, that is the ket enzime for glycolysis...and it also activates GLUCOKINASE, that is another anzime in glycolysis...so does it activates at the same time GLYCOGEN-SINTHESIS and GLYCOLYSYS??
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| yasmeen
Forum Guru
Topics: 67
Posts: 936
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yes it does it cause inc glucose utalization keeping blood glucose low.its an anabolic hormone so inc glycogen synthesis
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| ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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hi giovanni.
well, these thins aren't so difficult to understand; you just gotta think it logical.
when you eat lots of glucides, thy are broken into monosacharides and absorbed. because the absorbtion is done in a short period, the tendency is to increase dramaticaly the glicemia. but a healthy organism has to mantain a so-called HOMEOSTASIA (or whatever it is called in english). so the INSULIN is secreted.
now the insulin has the difficult task to "get rid of" the glucose so it deposits it in liver (as glycogen, activating the glycogenesis), in the muscle (where it enters durring muscle relaxation ONLY IN THE PRESENCE OF INSULIN, that's why diabetics are encouraged to do sports; where is deposited as glycogen also) and after that, if there is still some glucose left, as fatty acids (lypogenesis which is done first by breacking the glucose in glycolysis to pyruvate and after that acetyl-SCoA -> FA) Acetyl-SCoA is also used to synthesize proteins and sometimes ketone bodyes, also stimulated by insulin.
I hope I made it clear enough. Take care.
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| giovanni83
Forum Senior
Topics: 24
Posts: 125
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Thank you very much guys....now I understood!
Thanks!
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my msn messenger address is squadracalcetto@interfree.it ; my email address is giovanni83@email.it ; and my website is http://www.appuntimedicina.it ciao ciao
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