pearljam59
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A 51-year-old man comes to the physician because of fatigue, weakness, and joint pain for the past 5 days. For the past 9 months, he has been taking 10 mg of prednisone daily for severe rheumatoid arthritis. He tells the physician that he misplaced his medication last week and did not have it replaced. Which of the following mechanisms is most likely responsible for the development of these symptoms in this patient?
A. Adrenal atrophy due to suppression of ACTH secretion
B. Decreased conversion of cortisone to hydrocortisone
C. Downregulation of glucocorticoid receptors in target tissues
D. Increased clearance of endogenous adrenal steroids
E. Increased concentrations of plasma corticosteroid-binding globulin
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| skyhigh
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hypofunction of adrenal gland due to A.
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| mjl1717
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yes due to the ACTH- cortisol negative feedback
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| robin082006
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A
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| druas
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A...sudden cesation of steroids will lead to atrophy of adrenal..(that why always tapers off the steroids gradually)
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| vamsi2004
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druas ans is A. but ur reason is wrong.atrophy is due to chronic use. not due to sudden cessation.
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| docarchana
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yes atrophy is due to chronic use
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| klimt
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A
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| naqushbandi
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