doc179
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D?
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| nadiabarati
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pleas explain your answer! when do we have a substance in renal vein?
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| doc179
Forum Guru
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it can be in the renal vein if the substance never got ultra filtered into the glomerular filtrate or if it got reabsorbed somewhere in the nephron. In either case you can say it did not get cleared.
That is when it will be present in the renal vein.
There is no evidence in the Q to support A or B.
It could be C or D..pls let me know the ans if you know it..thanx
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| zaidsuror
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D
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| robin082006
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C
A substabce is not in renal veins when it is completely excreted. This mean that it is
- Filtered completely and not reabsorbed (e.g. low Inulin)--> A may be right
- partially filtered and the rest is completely secreted (low PAH)--> B and D may be right
Its content in urine is equal to that in plasma but urine is more condensed because water is reabsorbed. So I go with C.
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| nadiabarati
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%20 of renal plasma flow filtered into tubules. So what happen to the rest %80? It doesn't mean this %80 appear in renal vein except for the part that is secreted? Please let me know. I'm confused
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| mou
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why not A
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| Geroo
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answer is D.if a substance doesnt appear in renal vein it means it's completely secreted,like PAH in low dose so it's clearance equal renal plasma flow.
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| druas
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sound like D
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| mou
Forum Newbie
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yes ans is c ,robin is correct
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| seems
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so is teh rite answere C or D guys
plz now i m confused.i think its D cz ,th eplasma is completely cleared of that substance.
plz answere
thanx
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| aim
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I FEEL IT SHOULD BE --------D
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| fox
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bumped up for xpert opinion!! I personally feel D.
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| bangledoc
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A is the answer
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| Ancylostoma
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The answer is d,
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| brutus25
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Personally I think this is the prototype of "bad" question ; the expalnation given by robin082006 seems prety solid , both PAH and Inulin are cleared from plasma , another way to put it is that none of these substances appear in the renal vein either by
beeing completely filtered and not reabsorbed (e.g. low Inulin)--> A may be right
partially filtered and the rest is completely secreted (low PAH)--> B and D may be right
As we have no information of what happens with the substance (completely filtered and not reabsorbed , reabsorbed and secreted ...) the only choice that is "cleared" of any "reasonable doubt" is C 
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| Ancylostoma
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Brustus completly filtered means that all the inulin that is part of gfr is filtered, This is why we use inulin as a measure of GFR, and PAH as a measure of RBF. You have to remember fitration fraction is gfr/RPF. That means not all the blood to the kidney gets filtered. That is the fraction that is filtered of all the blood to the kidney. That means a 80 % of blood is not filtered. Remember that clearance is suppose to be the amount of plasma that is cleared of a substance. Calculated by unrine flow*unrine concentration/ plasma concentraion. Last you need to know that pah is freely filtered and secreted. If something is freely filtered, and there is no secretion or reabsorbtion, then the clearance of that substance is GFR. If something is freely filtered and completely secreted and therefore nothing is in the renal vein, then its clearance is renal plasma flow.
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| brutus25
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I doubled checked Ancylostoma , and my God you are completely right .Sorry I jumped to the gun.You were right.
Inulin is FREELY filtered ( not completely filtered )
PAH - on the other hand is COMPLETELY EXCRETED ( both filtration and secretion )
Therefore if it doesn`t appear in the renal vein it most definitely = RPF.
Thanks again
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