drpkaur
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A nine yr old boy was treated for six months with carbamazepine but recently has been experiencing breakthrough seizures on a more frequent basis.you are considering adding a second drug to this patient's antiseizure regimen..which of the following drugs is least likely to have a pharmacokinetic interaction with carbamazepine?
1.topiramate
2.tiagabine
3.levetiracetam
4.lamotrigine
5.zonisamide
make a reply with detailed explanation plz.
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| drpkaur
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hey somebody could answer it plz
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| robin082006
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Some og drugs that people don't know. I searched In Kaplan and FA but cannot have any idea to feel confident to answer this question. If I meet a question like this, just guess and go through.
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| tolito
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answer is LEVETIRACETAM.
LEVETIRACETAM: till date does not have any drug intreraction with hepatic inducers or inhibitors. it is largely not protein bound.
TOPIRAMATE Its serum concentration is reduced by 50% by inducers like carbamazepine
LAMOTRIGINE is metabolised in liver and half life is decreased by inducers like carbamazepine
TIAGABINE undergoes hepatic glucruonidation and oxidation
ZONISAMIDE; metabolism is affected by enzyme inducers like carbamazepine
SOURCES:
lippincott
http://www.rxlist.com/cgi/generic3/zonisamide_ad....
http://www.rxlist.com/cgi/generic3/keppra_ad.htm
Edited by tolito on 03/19/06 - 08:47 AM
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| drpkaur
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thanx tolito for ur good explanation
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