drbin wrote:
E Natural selection is process by which nature keeps fitness in population. so we know that sickle cell anemia provides protection from plasmodium falciparum malaria which is also common in african population. so by being a sickle cell trait(heterozygous carrier), the personis protected from malaria same time SCA is not manifested in phenotype(being autosomal recessive)
By exclusion
consanguinity can increase the chance of disease bs it is recessive but the consanguinity is not specific to African American population only so excluded
genetic drift increases the occurance of a disease but in not in this population as this is not a small group or race so excluded
gene flow decreases the occurance of disease
increased mutation rate - no studies suggest there is increased mutation risk in this population. new mutations are a rare phenomenon
and that leaves us with E
Good communication drbin!
Objectively speaking I believe the Jews at one point were known for consanguity resulting in Tay Sach, Neimann Pick, and various congenital deformities never before seen in the general population. Comments welcome.
Genetic drift has to do with minor antigenic changes resulting in infectious disease.
Edited by mjl1717 on 05/13/06 - 02:45 PM
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