vickimed
Forum Newbie
Topics: 5
Posts: 8
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Boys and girls:
NBME Questions need answer:
1. Several clinical trials has suggested that retinoic acid can induce remission in patients with acute promyelocytic leukemia. Such remission is related to the ability of retinoic acid to promote
which of the following:
A. Differentiation of leukemic cells
B. Differentiation of monocytes into macrophages
C. Geberation of cytotoxic lymphocytes
D. Production interferon
E. Repair of DNA damage
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2. A Pharmaceutical company has developed a drug that prevents egress of Mg2+ from the
/V-methyl-D-aspartate (NMDA) receptor. What is the most likely effect of this drug in a patient
with acute stroke?
A. Decreased risk for seizures due to hypomagnesemai
B. Facilitations of CA2+ entry into the neuron and enhancement of excitotoxin-mediated cell death
C. Hyperpolarization of membrane and conduction block
D. Prevention of CA2+ entry into the neuron and reduction of excitotoxin-mediated cell death
E. Rapid depolarization of membrane with lowering of the seizure threshold
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3. Which of the following anti-microbial agents is most likely to be administered orally for the
treatment of potentially serious systemic infections because of its predictable bio-availability
A. Amphotericin B
B. Ciprofloxacin
C. Gentamicin
D. Polymyxin B
E. Vancomycin
*****
4. A 25 Yr-old woman at 32 weeks’ gestation begins taking a drug to delay the onset of preterm labor. After the first dose, she notices tremulousness in her hands. Which of the following types of receptors is most likely to be involved in this effects?
A. α1-Adrenergic
B. β2- Adrenergic
C. Dopaminergic (D1)
D. Muscarinic (M1)
E. NMDA
Many Thanks!
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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A, D, B, B
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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1)A
2)B
4)B
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| robin082006
Forum Hero
Topics: 471
Posts: 5,125
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1.A
2. B
3. B
4. B
___________________
The Key to Succeed is Patience.
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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Now, B makes sense for # 2 . Presence of Mg2+ in the NMDA receptor helps ca+ influx, and therefore excitotoxic cell death.
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