tough immuno Q, plz explain NBME 2 S 1

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tough immuno Q, plz explain NBME 2 S 1

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6 Posts

nadiabarati

03/14/06 - 07:43 AM

. Tumor necrosis factor is the primary mediator of host responses initiated by lipopolysaccharide (LPS) and leading to septic shock. LPS-mediated activation of transcription most likely depends on which of the following transcription factors?
A ) c-ras
B ) Nuclear factor-kappa B
C ) p53
D ) Rb protein
E ) VP-16 (etoposide)
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jonathon
Forum Senior

Topics: 25
Posts: 62

03/19/06 - 12:52 AM

B. Nuclear factor-kappa B

http://www.comparative-hepatology.com/content/3/S...

Cedrick
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07/09/06 - 02:06 AM

Yes !

B.- nuclear factor kappa B

truedeam59
Forum Elite

Topics: 29
Posts: 145

07/21/06 - 08:14 PM

take a look
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?i...

MichaelGhali
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Posts: 1

07/22/06 - 08:22 PM

B. NFkappaB. Also, possibly a high yield fact for USMLE 1, this is important for the synthesis of IL-2. The main mechanism of action for immunosuppression of glucocorticoids is through inhibition of the action of this chemical. C-ras is a protein involved in accelerating the cell cycle, p53 slows it down if there is damage to DNA, Rb is the retinoblastoma protein, which sequesters important cell-cycle promoting molecules, which are released as the cycle progresses, and I have no idea what VP 16 is.

young_doc
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07/25/06 - 03:16 PM

The question basically asks which Transcription factor is needed to make TNF.

NKFB is the only one on the list even related to cytokine production.

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