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. Tumor necrosis factor is the primary mediator of host responses initiated by lipopolysaccharide (LPS) and leading to septic shock. LPS-mediated activation of transcription most likely depends on which of the following transcription factors? A ) c-ras B ) Nuclear factor-kappa B C ) p53 D ) Rb protein E ) VP-16 (etoposide) Follow
B. NFkappaB. Also, possibly a high yield fact for USMLE 1, this is important for the synthesis of IL-2. The main mechanism of action for immunosuppression of glucocorticoids is through inhibition of the action of this chemical. C-ras is a protein involved in accelerating the cell cycle, p53 slows it down if there is damage to DNA, Rb is the retinoblastoma protein, which sequesters important cell-cycle promoting molecules, which are released as the cycle progresses, and I have no idea what VP 16 is.
young_doc Forum Guru
Topics: 58 Posts: 737
07/25/06 - 01:16 PM
#6
The question basically asks which Transcription factor is needed to make TNF.
NKFB is the only one on the list even related to cytokine production. ___________________ First Aid is my Bible...
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