Janka
Forum Senior
Topics: 28
Posts: 146
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ok that's a tough one.
i only know that a defect in CD40L results in Hyper IgM syndrome, because class switch does not work anymore. so we have more than enough IgM but none of the other Ig classes. so now we have to figure out which antibody response of the above would be IgM.
suggestions?
i would go for D, cause it sounds reasonable, i don't know. i don't see any difference between A and B, and for C we certainly would ---
WAIT now that i think about it i would go for C - they produce anti-gp120 IgM first, right?
not sure now. but i say C. what do you guys think?
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| nadiabarati
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the right answer is A.
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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Is it b/c the extracellular surface "flagellin" activates the alternate pathway of the complement system, whereas the penicillin, gp120, and Ecoli "porin" all require TCELL-BCELL interaction via the CD40ligand.?
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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This is what I have found:Mammals tend to have a strong immune system response to flagellin since it's one of the most common proteins in some disease-causing bacteria. In mammals, there is a specific T-cell receptor for flagellin. Bacteria, of course, respond by trying to overcome the response; some can switch between different flagellin genes to try to trick mammalian immune cells.
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| Janka
Forum Senior
Topics: 28
Posts: 146
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got it:
there is no t-cell receptor for flagellin but a specific toll like receptor -> TLR5
so the immune response to flagellin has nothing to do with antibody production,
the !innate! immune system responds when recognizing flagellin via TLR5.
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| huzefa
Forum Junior
Topics: 2
Posts: 66
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I know this q has been answered, but can somebody clear something up for me? I read somewhere that gp120 antigen is constantly changing its antigenicity; so the IgM titer for gp120 stays high in HIV ppl even when the CD4 count is low because it's B-cell mediated. Am I just confused about this?
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| robin082006
Forum Hero
Topics: 471
Posts: 5,125
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good q
___________________
The Key to Succeed is Patience.
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| truedeam59
Forum Elite
Topics: 29
Posts: 145
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NADIABARATI. COULD U PLEASE TELL ME THE SOURCE OF YOUR QUESTION. i AM TRYING TO FIND MORE BUT COULD'T?
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