| Author | 16 Posts |
nadiabarati
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1. Pt. on chemo has fever and high T cell count asked what cytokin was responsible for his fever?
2. A 1-year-old boy is brought to the emergency department because he is having difficulty breathing after drinking water that contains nitrate. He is cyanotic. Blood drawn for laboratory studies is chocolate-colored. His hemoglobin most likely has which of the following properties?
A. Decreased glycosylation
B. Increased binding of 2,3-bisphosphoglycerate
C. Increased proportion of Fe3+
D. Presence of Beta subunits only
E. Sickle cell mutation
3. A 30-year-old man develops fever, malaise, and a rash on his palms and soles. He frequently hikes in a wooded area near his home and removed an engorged tick from his thigh 1 week ago. Laboratory studies show a leukocyte count of 5500/mm3, a platelet count of 85,000/mm3, and a serum sodium concentration of 128 mEq/L. Which of the following best describes the mechanism of action of the drug of first choice for this condition?
A. Alters capillary permeability
B. Binds to Beta-lactamases
C. Blocks protein synthesis
D. Inhibits transpeptidase
E. Opens ion channels
4. A 40-year-old man comes to the physician because of a 3-month history of midepigastric discomfort that is relieved by eating. His vital signs are normal. Physical examination shows mild epigastric tenderness to palpation. Test of the stool for occult blood is positive. Endoscopy shows a gastric ulcer with heaped-up margins surrounded by edema and inflammation. A biopsy specimen is placed in media containing phenolphthalein. En route to the laboratory, the color of the media changes from yellow to red. Which of the following best explains the change in media pH?
A. Bacterial catalase
B. Bacterial CO2 production
C. Bacterial oxidase
D. Bacterial urease
E. Gastric acid
5. A 10-month-old boy with hemoglobin SS disease is brought to the emergency department by his parents because of severe pain in his feet for 2 hours. He appears acutely ill and is crying. Vital signs are normal except for a pulse of 160/min. Physical examination shows splenomegaly and edematous, tender feet. Laboratory studies show a hemoglobin concentration of 7 g/dL and a reticulocyte count of 12%. A peripheral blood smear shows target cells, poikilocytes, and sickled erythrocytes. Which of the following processes most likely caused the sickled erythrocytes in this patient?
A. Decreased interaction of hemoglobin S with spectrin upon deoxygenation
B. Inability of abnormal beta-chains to form tetramers upon deoxygenation
C. Inability of abnormal beta-chains to form tetramers upon oxyge
6. A 5-year-old boy who recently emigrated from West Africa is brought to the physician by his mother for treatment of recurrent follicular conjunctivitis. His father and uncle have had similar symptoms and are now blind. Which of the following is the most likely causal organism?
A. Adenovirus
B. Chlamydia trachomatis
C. Herpes simplex virus
D. Neisseria gonorrhoeae
E. Streptococcus pneumoniae
Please explain your answers, brief explanations are better that nothing at all
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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2nd Q the ans C as it is metheamoglobinemia. nitrates and sulfa drugs reduce or oxidise ..sorry I always get confused abt that... iron Fe2+ to Fe3+
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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for the 4th one the ans is D as it helicobacter pylori which has urease in it..can not tell you anything more than that sorry...know only this much abt it.
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| nadiabarati
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thanks. I'd also gone for the same answers.
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| steppingsam
Forum Junior
Topics: 9
Posts: 69
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Q 1: Cytokine IL-1, Interleukin 1 increase synthesis of PGE-2 in Hypothalamus.
Q 2: Answer is C, Increase Fe 3+ It is Oxydized Iron, Oxygen cannot bind to it, called Methemoglobin, you need Ferous Iron which is reduced Iron Fe 2+
Q 3:
Q 4: Answer is D: H pylori is a Urease positive organism
Q 5: Answer A: Decreased interaction of hemoglobin S with spectrin upon deoxygenation, Hemoglobin polymerizes at low Oxygen tension.
Q 6: Answer B: Chlamydia trachomatis
Edited by steppingsam on 03/08/06 - 09:31 PM
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| general malaise
Forum Guru
Topics: 14
Posts: 433
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3..C rocky mountain spotted fever? it can have DIC which would explain low platelets. treatment is tetracycline which inhibits protein synthesis at 30s rybosomal subunit
6..B chlamydia causes chronic conjunctivitis endemic to africa and asia which can lead to blindness
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| nadiabarati
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I go for these answers:
1.IL-1
2.C
3.C
4.D
5. B
6. B
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| mazinger
Forum Guru
Topics: 46
Posts: 918
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well guys agree with most of you in the answers, but for first question should be considering IL-6 as a possible candidate.. Mmmm not sure IL-1 is related to lymphocitosis.. if Im wrong could you please explain. But, IL-6 sounds better to me.
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| paba
Forum Senior
Topics: 15
Posts: 57
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i think 5 is a
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| rman
Forum Senior
Topics: 39
Posts: 123
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5 is A; spectrin is hereidatary spherocytosis
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| robin082006
Forum Hero
Topics: 471
Posts: 5,125
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1. Pt. on chemo has fever and high T cell count asked what cytokin was responsible for his fever?
Interleukine 1 or interleukine 6
2. A 1-year-old boy is brought to the emergency department because he is having difficulty breathing after drinking water that contains nitrate. He is cyanotic. Blood drawn for laboratory studies is chocolate-colored. His hemoglobin most likely has which of the following properties?
A. Decreased glycosylation
B. Increased binding of 2,3-bisphosphoglycerate
C. Increased proportion of Fe3+
D. Presence of Beta subunits only
E. Sickle cell mutation
C
3. A 30-year-old man develops fever, malaise, and a rash on his palms and soles. He frequently hikes in a wooded area near his home and removed an engorged tick from his thigh 1 week ago. Laboratory studies show a leukocyte count of 5500/mm3, a platelet count of 85,000/mm3, and a serum sodium concentration of 128 mEq/L. Which of the following best describes the mechanism of action of the drug of first choice for this condition?
A. Alters capillary permeability
B. Binds to Beta-lactamases
C. Blocks protein synthesis
D. Inhibits transpeptidase
E. Opens ion channels
B, RMSF
4. A 40-year-old man comes to the physician because of a 3-month history of midepigastric discomfort that is relieved by eating. His vital signs are normal. Physical examination shows mild epigastric tenderness to palpation. Test of the stool for occult blood is positive. Endoscopy shows a gastric ulcer with heaped-up margins surrounded by edema and inflammation. A biopsy specimen is placed in media containing phenolphthalein. En route to the laboratory, the color of the media changes from yellow to red. Which of the following best explains the change in media pH?
A. Bacterial catalase
B. Bacterial CO2 production
C. Bacterial oxidase
D. Bacterial urease
E. Gastric acid
D
5. A 10-month-old boy with hemoglobin SS disease is brought to the emergency department by his parents because of severe pain in his feet for 2 hours. He appears acutely ill and is crying. Vital signs are normal except for a pulse of 160/min. Physical examination shows splenomegaly and edematous, tender feet. Laboratory studies show a hemoglobin concentration of 7 g/dL and a reticulocyte count of 12%. A peripheral blood smear shows target cells, poikilocytes, and sickled erythrocytes. Which of the following processes most likely caused the sickled erythrocytes in this patient?
A. Decreased interaction of hemoglobin S with spectrin upon deoxygenation
B. Inability of abnormal beta-chains to form tetramers upon deoxygenation
C. Inability of abnormal beta-chains to form tetramers upon oxyge
this question is incomplete, I think A,B,C are not suitable, need other choices
6. A 5-year-old boy who recently emigrated from West Africa is brought to the physician by his mother for treatment of recurrent follicular conjunctivitis. His father and uncle have had similar symptoms and are now blind. Which of the following is the most likely causal organism?
A. Adenovirus
B. Chlamydia trachomatis
C. Herpes simplex virus
D. Neisseria gonorrhoeae
E. Streptococcus pneumoniae
B
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| alexaE
Forum Elite
Topics: 23
Posts: 334
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1 is IL 6
because IL 6 is secreted by the T cells and it also induces fever it is called a pyrogen as well
whereas IL1 is made in the macrophages
for the rest of the answers, i agree with nadia
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| rman
Forum Senior
Topics: 39
Posts: 123
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Ah, good call AlexaE
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| Chrales
Forum Newbie
Topics: 2
Posts: 30
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Question 3
it's answer C for sure:
He removes an engored tick: So it can only be a tick related disease
--> Rickettsia Rickettsii (Rocky mountain spotted fever) fits in very well
(remember the rash that involves palms and soles and then spread centripetally over the trunk --> here: havent occured yet)
So treatment of choice is a tetracycline (inhibition of the Elongation step in Proteinsynthesis), thus the correct answer is C
Question 5:
The correct answer is missing. "HBS polymerizes when deoxygenated" is the correct one: Here a small text passage:
Deoxygenation of the heme moiety of HbS leads to hydrophobic interactions between adjacent HbS molecules, which then aggregate into larger polymers, distorting the red blood cell (RBC) into the classic sickle shape.
I agree with all the other answer choices
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| dericanthony
Forum Newbie
Topics: 2
Posts: 28
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i think that 1 is IL-1 --- usually affects the hypothalamus
2 nitrates, nitrities and sulfur and dapsone cause metHB the answer is c
3 the patient has rocky mountain spotted fever -- tetracyclines are the treatment of choice
MOA protein synthesis inhibitions
4 ulcers are usually infected with H.pylori -- this is urase positive
5 i have seen this question before and i think that you did not give the corret option
i think that the answer had the option with reduced arterial oxygen content
6 6 is B
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| KOBITA
Forum Junior
Topics: 14
Posts: 53
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For question 5 the rest of the options are........D)Increased interaction of Hemoglobin S with spectrin upon oxygenation E)Spontaneous polymarization of hemoglobin S upon deoxygenation F) Spontaneous polymariazation of Hemoglobin S upon oxygenation.
My answer is E... any comment !!!
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