doctor81
Forum Elite
Topics: 34
Posts: 240
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in the lectures of infectiuos disease,Dr conrad says that we should not use methicillin in Methicillin senstive staph aureus.
Why?
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| DrS
Forum Elite
Topics: 32
Posts: 338
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cos theres no drug called methicillin used in clinical practice. it is only used in the laboratory to do sensitivity testing.
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| doctor81
Forum Elite
Topics: 34
Posts: 240
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thanks.
it is not used because of the interstitial nephritis it causes.
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| achilles
Forum Guru
Topics: 90
Posts: 1,227
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just adding a few points-
Beta-lactamase-producing strains of methicillin-susceptible S. aureus (MSSA) preferably are treated with a semi-synthetic penicillin (e.g., intravenous nafcillin, oxacillin, oral dicloxacillin) in patients not allergic to penicillin. First-generation cephalosporins (e.g., oral cephalexin, intravenous cefazolin) are an alternative. Vancomycin should only be used for the treatment of MSSA in patients allergic to penicillins because of overuse and development of resistant organisms, and because clearance of bacteremia may be slow.
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