Medusin
Forum Elite
Topics: 19
Posts: 296
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I am sure hypertrphy is reversible. That is why it is considered an adaptive mechanism to environmental stress. It results from cellular adaptation to increased workload, like the heart during chronic exercise or during hypertensive heart disease. Therefore it can be phsyiological or pathological.
To reverse hypertrophy in this example you have to decrease the workload of the heart so it can go back to its original state.
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| nadiabarati
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how about buttocks,thigh and abdomen? how can you guide your patient if she asks your advice?
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| somerset
Forum Newbie
Topics: 0
Posts: 1
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hi , i don't think that hypertrophy is reversible, because the cells are arrested in G2 phase with 4n, so if it is reversible it needs to reverse the S-phase which is not possible, nevertheless, i think that muscular hypertrophy (for example is a weight builder) is known to decrease if the athlete doesn't continue doing exercises, and i think that is atrophy of the hypertrophied muscle
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| vinaysaini19
Forum Junior
Topics: 16
Posts: 65
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Hypertrophy is reversible. For patient with butts and thighs (pelvic obesity) I think that has to do with number of fat cells and how much they are loaded with fat i.e both hypertrophy and hyperplasia.
For these patients exercise is the recommended regimen which will decrease the size of fat cells but not their number.
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| ManuNastai
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vinaysaini is absolutely right. it hasn't so much to do with G2, S phases, but with the term's definitions:
HYPERTROPHY = a increase in an organ's weight, size and function due to the increase of the cell's size
HYPERPLASIA = a increase in an organ's weight, size and function due to the increase of the cell's number
Hypertrophy and only this one is almost exclusively found in the muscle cells (every kind). Of course it is reversible! For example the blader muscle hypertrophy in Benign hyperplasia of the prostate.. if the guy has surgery for the removal of the stenosis, the muscle doesn't have to work harder and it atrophies. Same thing with obese patients who develop cancer -> they develop marasmus
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