rei
Forum Elite
Topics: 67
Posts: 126
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Anti-A and anti-B are naturally occurring IgM which can fix complement.
I dont reli understand what is meant by "fix complement"
can someone plz kindly help??
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| cyra
Moderator
Topics: 29
Posts: 844
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Once an antigen-antibody complex forms with IgM antibodies it binds to the complement and inactivates it so that it cannot take part in another antigen antibody combination....and therefore "fixes" it.
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| rei
Forum Elite
Topics: 67
Posts: 126
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so it means that, when IgM binds with an antigen, this Ag-Ab complex can bind to the complement and inactivate the complement, right??
but then i hv another question, why intravascular hemolysis occurs becoz IgM can fix complement, while extravascular hemolysis occurs becoz IgG cannot fix complement??
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| enthu
Forum Junior
Topics: 14
Posts: 42
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complement fixation causing the inactivation of complement is more of an invitro phenomenon and can be rephrased as-----> the cpomplement is fixed by the antigen antibody and is not available for use to lyse the sensitized RBC that are subsequently added( Complement fixation reaction is said to be positive)..but inside the body if antigen atibody bind to complement fix it, their occurs complement mediated lysis.
hope that helps.
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| rei
Forum Elite
Topics: 67
Posts: 126
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Thank you very much
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