malinda
Forum Guru
Topics: 162
Posts: 654
|
what are the main point to differentiate these two on exam?
___________________
I CAN DO IT.
|
| krsna
Forum Senior
Topics: 1
Posts: 211
|
in g6pd heinz bodies are seen but not in pk deficiency
there is inc 2,3-BPG in PK defcn. but not in g6pd.also g6pd has a defective NADP oxidase sysytem leading to chr. granulomatous disease
|
| malinda
Forum Guru
Topics: 162
Posts: 654
|
what about inheritence patterns?
___________________
I CAN DO IT.
|
| mazinger
Forum Guru
Topics: 46
Posts: 917
|
Easier way to figure this out.. G6PD deficiency cannot make NADPH and the severity of this deficit is variable among individuals, MOST of these patients have a moderate deficit and only have symptoms while they are under oxidative stress situations.. Infections, drugs, fava beans.. All of these situations increase O2 free radicals which make these patients have hemolytic crisis, Heinz bodies viewed with supravital stains and so on. They dont have enough NADPH to feed glutathion peroxidase pathway so their RBCS cannot clear these newly formed free radicals. Severe cases of G6PD def may be related to a severe absence of NADPH, there would be no substrate for NADPH oxidase (which is normal in these individuals), and it may act as a chronic granulomatous dzs in a way. PK deficiency you dont have the enzyme to make PEP to pyruvate, therefore you cannot make anaerobic glycolysis (lactate) from pyruvate. These patients have a persistent hemolytic anemia and the glycolytic pathway ends up doind 2,3 BPG shifting the curve to the right.. An accumulation of NADH will eventually stop glycolisis and the RBCs will lyse persistently and not periodically..
___________________
Ultraseven X
|
| mazinger
Forum Guru
Topics: 46
Posts: 917
|
G6PD X linked recessive, PK dont know
___________________
Ultraseven X
|
| reet
Forum Fanatic
Topics: 152
Posts: 1,411
|
mazinger isnt PK deficiency reccesive ds??
___________________
Live as u were to die tommorow. Learn as if u were to live forever.
|
| mjl1717
Forum Hero
Topics: 955
Posts: 5,451
|
Id say PK is autosomal reccesive
___________________
Smell the coffee! "Is That an Osler move??"
|
| mazinger
Forum Guru
Topics: 46
Posts: 917
|
... thx guys didnt know that
___________________
Ultraseven X
|
|
| |
| | | | | | | | |
