robin082006
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137. A 14-month-old male infant presents with an enlarging abdominal
mass. Laboratory examination reveals increased urinary levels of
metanephrine and VMA (vanillylmandelic acid). A histologic section from
the mass reveals a tumor composed of small, primitive-appearing cells with
hyperchromatic nuclei and little to no cytoplasm. Occasional focal groups
of tumor cells are arranged in a ring around a central space. What is the
correct diagnosis for this tumor?
a. Adrenal cortical carcinoma
b. Ganglioneuroma
c. Nephroblastoma
d. Neuroblastoma
e. Pheochromocytoma
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| mazinger
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d
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original mazinger z
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| nadiabarati
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d
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| doc179
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one might jump at first sight and think it is e.
But read pg 421-422 in goljan.
Pheochromocytoma and neuroblastoma are the two adrenal tumors that hypersecrete.
neuroblastomas (malignant) are one of the commonest abdominal tumors found in children, typically around age 2, and characterized by high VMA and metanephrine levels in urine.
Why not pheochromocytoma:
90% are benign, 90% are in adults.
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| robin082006
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answer is D
Hint in this question is Rosette structure: focal groups
of tumor cells are arranged in a ring around a central space.
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| prader-willi
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YES..D
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hang on in there......u will survive....
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| docarchana
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thanx doc 179 & robin.
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