DrVirgo
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7. A 10-year-old boy with asthma has been receiving oral hydrocortisone daily in increasing doses for the past 2 years. He is obese and has growth retardation and edema of his lower limbs. Which of the following is the most likely explanation for the edema?
A) The drug binds to both glucocorticoid and mineralocorticoid receptors
B) The drug is converted to a mineralocorticoid in the liver
C) Pulmonary production of angiotensin is increased
D) Renin activity is increased because of stress
E) Secretion of ADH (vasopressin) is increased because of stress
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| kleila
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 i looked ,i have no idea , does anyone?
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| sunshine77
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A?
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| mazinger
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a
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| nadiabarati
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how about B? Is it possible?
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| robin082006
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A
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| robin082006
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I'm sure the correct answer is A.
I saw a similar question when doing pretest series, explanation is that glucocorticoid, except dexamethasone, has some mineralocorticoid effects and its long-term use results in edema, hypertension...
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| nadiabarati
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yes robin, glucocorticoids have some mineralocorticoid activity also! But the problem is that, what is the mechanism of action?
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| robin082006
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It acts as a weak mineralocorticoid. (similar mechanism with aldosterone?)
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