DrVirgo
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5. A49-year-old man is brought to the emergency department because of chest pain for 20 minutes. Immediately before underging emergency coronary thrombolysis, he has a 95% stenosis of his left anterior descending coronary artery is widely patent, but his ejection fraction has decreased to 30%. Which of the following is the most likely cause of the decreased ejection fraction following successful thrombolysis?
A) Catecholamine-induced myocardial apoptosis
B) Catecholamine-induced myocardial hypertrophy
C) Decreased myocardial adenosine production
D) Intramyocardial calcium depletion
E) Superoxide-mediated myocardial injury
please explain.
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| usmle99
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is the Q right? should not it be saying "after undergoing thrombolysis"? and if what I am thinking is correct ..its reperfusion injury and so the ans is E
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| endocrine
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E
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| general malaise
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E, reperfusion injury due to generation of free radicals
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| nadiabarati
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usmle99, the question is right. it's said FOLLOWING successful thromolysis that means After undergoing thrombolysis. I read BRS for pathology and there isn't anything about reperfusion injury in it!!! Can you please explain it?
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| general malaise
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check pg 4 at the bottom in brs path 2nd ed
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| guangyu
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e
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| nadiabarati
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general malaise. yes in page 4 it says free radicals are produced during reperfusion after ischemic injury! only this! and no more explanation!
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| general malaise
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free radicals cause injury thru lipid peroxidation of membranes, oxidative modification of proteins and lesion in dna
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"El respeto al derecho ajeno es la paz" Benito Juarez
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| druas
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i agree with general malaise...
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| dipti
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hey general maiaise,can you tell me in which book free radical injury is given the best?as nadiabarati is right,there is no much explanation about that.can you please tell ?
thanks.
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| usmle99
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goljan is good
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| general malaise
Forum Guru
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yes, brs only mentions it in one line, i had to annotate it from robbins
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