malinda
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A 58-year-old woman had a mitral valve replacement, and was placed on anticoagulants and prophylactic
antibiotics following her surgery. Five days after her surgery, she developed a sharply demarcated,
erythematous rash on her left thigh . Two days after the rash appeared, large hemorrhagic bullae began to form
in the area of the rash. Which of the following medications most likely caused the patient's rash?
A. Aspirin
B. Cefazolin
C. Heparin
D. Vancomycin
E. Warfarin
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| druas
Forum Elite
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E..warfarin
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| malinda
Forum Guru
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yes warfarin.But I never heard about this specific type of rash caused by warfarin
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| druas
Forum Elite
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warfarin causes skin necrosis...i dont know the exact mechanism (also some times referred as purple toe syndrome)
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| usmle99
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warfarin transiently decreases protein C cos it has the shortest half life and hence the extrinsic pathway is inhibited but intrinsic pathway is still active and causes hypercoagulation resulting in dermal vascular thrombosis and necrosis.
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| robin082006
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good explanation
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