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Kaplan Qbank USMLE



Author7 Posts
  #1

can someone explain the relationship between Ca++, PTH and vit D?

  #2

Vit D3

Enhances Ca2+ absorption from intestine by forming:

calcium-stimulated ATPase and calcium-binding protein in brush border of intestinal epithelial cells, both increasing absorbtion of Ca2+.

Also it promotes bone calcification by causing Ca2+ transport from ECF thru osteocytic membrane into bone fluid.

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PTH

Inc. blood Ca2+ conc due to inc. calcium absorption from bone due to activation of “Calcium pump” in osteocytic membrane and by activating ‘osteoclasts’.

Also decreses calcium excretion by kidneys and increases Ca2+absorption in distal-tubules & collecting ducts.

Parathyroid hormone also converts inactive vit D to its active form.


  #3

..i need to know the funtion of de Ca in the neurotrasmition ??please

  #4

Ca binding increases the activity of receptors for the neurotransmitters..thereby facilitating their uptake and processing for subsequent neurotransmission.


  #5

What happens to Ca+ and Phosphate levels in chronic renal failure?(leading to secondary hyperparthyroidism.)

Edited by skyhigh on 03/16/06 - 12:46 PM

  #6

chronic renal failure, the kidney dump less phosphate -> serum phosphate increase -> PTH decrease -> ca++ decrease.

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  #7

sorry I messed up.

chronic renal failure, the kidney dump less phosphate -> serum phosphate increase -> ca++ decrease -> PTH increase.


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