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49. Endothelial cells of the postcapillary venules increase expression of intercellular adhesion molecule-1 (ICAM-1) in response to cytokines. The increased expression of ICAM-1 results directly in which of the following neutrophil functions?
A) Activation
B) Adherence
C) Chemotaxis
D) Demargination
E) Transmigration
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| reet
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2..
A previously asymptomatic 42-year-old man who has been seropositive for HIV for 4 years comes to the physician because of the recent onset of fever, cough, and weight loss. An x-ray film of the chest shows bilateral pulmonary infiltrates. A methenamine silver-stained preparation of bronchoalveolar lavage fluid is shown. Which of the following immunologic abnormalities most likely led to the development of this pulmonary <?
A) Circulating immune complex-induced injury
B) Decrease in the number of CD4+ T lymphocytes
C) Inactivation of pulmonary macrophages
D) Increase in selective cytotoxic CD8+ T-lymphocyte activity
E) Loss of natural killer cell function process?
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| reet
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1.E
2..B
?????
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| Geroo
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I think 1.B
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| reet
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yes,, geroo..i agree with you.. may be ( DIRECTLY..) is pointed out in question
but ICAM can CAUSE adhesion n transmigration of all leucocytes
So wht about PECAM???? only transmigration by-- PECAM...???
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| mangoshaikh
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i think its B & B
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| 26malik
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1. B
2. B
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| ramo7
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1 e
2 b
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| doc179
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I will go with geroo for B and B for both of the questions
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| pearljam59
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1 B
2 B
Regarding the first one, neutrophils can increase synthesis of a CAM that is involved in rolling phase. But the ? states it is CAM from the endothelial cell which is involved in arrest and adhesion.
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| jagian75
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is not ICAM responsible for the homing to lymph node and migration to inflammatory site. acting thru the lfa 1 ligand? then shoiuldnt it be transmigration? e?
if its lfa 3 then it will act thru the t cell interaction then it will adhesion . someone correct me if i am wrong
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| r_albayunen
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B
B
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| surgeon99
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ya it is b and b
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