DrVirgo
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17. A genetic element is found to contain several genes and to catalyze its own movement within and between chromosomes. Inverted 35-nucleotide repeats are present at the ends of this genetic element. This genetic element in hepatocytes is incapable of replicating independently. Based on this description, this genetic element is best categorized as which of the following?<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
A) Complex transposon
B) Insertion sequence
C) Plasmid
D) Regulon
1. BIOCHEM RXNS
ΔG0'
V ↔ W – 4.0
W ↔ X +0.4
X ↔ Y – 3.4
Y ↔ Z + 5.7
From the values of ΔG0' given in the table, which compound in the overall metabolic pathway V ↔ W ↔ X ↔ Y ↔ Z will accumulate in the largest amount at equilibrium?
A) V
B) W
C) X
D) Y
E) Z
2. A 13-month-old girl has a history of recurrent bacterial infections. Production of O2–, H2O2, and ·OH by neutrophils is normal and production of HOCl is decreased following stimulation by opsonized bacteria. The most likely cause is deficiency of
A) catalase
B) glutathione peroxidase
C) myeloperoxidase
D) NADPH oxidase
E) superoxide dismutase
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| reet
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1......? A
2. D
3. C
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| nadiabarati
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A
D
C
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| skyhigh
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could 17 be C?
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| reet
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can anyone explain first q CHOICES??
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| drk1980
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for the second Q....isnt it E)- Z?......the energy of the 'overall' metabolic pathway is a sum of energy of each individual reaction ...(-4.0)+(+0.4)+(-3.4)+(+5.7) = -1.3 ...wch indicates that its a spontaneous reaction moving towards the right....ending up producing the last product in large amounts...wch is Z!
correct me plz...
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| nadiabarati
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I think you are right drk1980! Yes I didn't pay attention to the whole and just considered the last reaction. Yes the answer must be z
skyhigh, plasmid CAN replicate independently, so it can't be the answer
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| endocrine
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catalys mvmnt btn n withn chr:jumping genes:complex transposons!!!!
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| msyamp
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hey guys. thats not the answer. the reaction taking that maximum energy will be the rate limiting one. here it is Y>>Z . so this is rate limiting. Y shud accumilate in considerable amount to take the reaction forward. Ans is Y
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| msyamp
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nadiabarati has ACED
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| nadiabarati
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I didn't get your explanation about why Y is the right answer, dear msyamp!
I also didn't get the meaning of has ACED?!
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| msyamp
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hmmm
ok
if you have a series of gutters and water is flowing in a direction.and each gutter is having a threshold to stop the water from flowing. now in equilibrium the gutter with highest threshold will stop maximum amount of water before it. so thats the same way.
reaction Y to Z has +5.7 reaction energy that is it needs that much energy. the enzymes would be facilitated only when enough Y accumilates (you know that high conc of substrate would have a positive conf change and facilitates enzyme) the reaction goes on. so at equilibrium the Y accumilates more than anyother substrate in the reaction.
well ACEing some thing is that you gave all right answers.
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| drk1980
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nice example MSYAMP!  .......but plz be gentle wth me....i think i am gonna differ from ur answer.  The Q appears to be asking abt wch direction is the overall metabolic pathway going at equilibrium. Most definitely the pathway is spontaneous and is moving forward coz deltaG of the entire process is negative.
If the Q had hinted otherwise and if each reaction were to be taken individually..i'd agree wth ur answer 100%. Sorry iam unable to explain descriptively....but i hope u get the drift.. lemme know my slip up..
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| msyamp
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yes drk i agree with what you say. but here he is not asking that. the answer would be Y. if he has given the individual steps and asked this ans is to be thought like that as i said. see he also metion at equilibrium. i hope sme one finds the answer given to this.
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