DrVirgo
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40. The sulfonylureas exert their hypoglycemic effect by blocking which of the following channels?
A ) Ca2+
B ) Cl–
C ) K+
D ) Mg2+
E ) Na
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| mjl1717
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answer-B- by blocking An ATP-sensitive K channel but this causes INFLUX of Ca2+
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| DrVirgo
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mlj:
Answer B is a Cl channel.
did you mean C) K channel?
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| DrVirgo
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I think its C. K Channel.
OSU's block K-Channel in beta cell membrane, cell depolarizes, insulin is released due to increase Ca influx.
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| Nan
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Sulfonylureas bind to an ATP-dependent K+ channel on the cell membrane of pancreatic beta cells. This inhibits outflux of potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin. Answer is C
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