skyhigh
Forum Guru
Topics: 105
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What are MOA'S of Tiagabene and Vigabatrin?
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| Nan
Forum Senior
Topics: 12
Posts: 159
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Tiagbine - blocks GABA transporter. Tiagabine works to block GABA from being re-absorbed too quickly into the tissues, thereby increasing the amount available to bind to neurons.
Vigabatrin is an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of GABA, which increases the level of GABA in the synapses.
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