 |  challengin Q plz explain NBME 2 S 1
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| Author | 16 Posts |
nadiabarati
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27. A 23-year-old woman has prolonged episodes of wheezing, dyspnea, and anxiety that are relieved by â-adrenergic agonists. The major mediator of her condition is
A) bradykinin
B) eosinophil chemotactic factors
C) leukotrienes
D) prostaglandin E
E) thromboxane
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| druas
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ok everyone ..lets first try to come upto the diagnosis first...then answer
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| msyamp
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it closely corresponds to asthma. but a agonist???
ok. let us consider other possibilities. panic attacks, pulmonary edema, pulm eosinphilia. i think it doesnt have a agonist as treatment.
we use epinephrine in asthma for bronchodialation and it is also a agonist.
hmmm. i think it is a printing mistake. hahahaha
what answer did he give bharathi???
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| Natasa
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it's asthma(reccurent attacks and of course she's anxious about it-wouldnt you be?) and the answer is C.(leucotrienes).It is releived by adrenergic agonists that cause bronchoidilatation.(acting on B2 receptors )
C.
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| skyhigh
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don't leukotrienes cause bronchoconstriction, therefore an adrenergic agonist could help.....
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| druas
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i have the same thought as natasa..
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| Natasa
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Beta 2 agonists are helping in that case-like albuterol,isoproterenol,salmeterol
NOT Alpha 2 agonists.
Epinephrine also acts on Beta 2 Receptors and also no Alpha 1 to produce bronchodilatation
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| Natasa
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Come on,its an easy one-it's just the typing error that makes it look difficult.
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| nadiabarati
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Natasa, what do you mean by typing error? there isn't any typing error in the question! your explanation is great as always, thanks
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| DrVirgo
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I agree with you all that is is asthma.
Leukotriene is the mediator that causes bronchoconstriction.
I think the question should have said BETA agonist and NOT alpha agonist, as beta-agonists can relieve symptoms by causing bronchodilation.
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| Natasa
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Right-Its Beta 2 action,
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| chicosalgueiro
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..or it could be angioneurotic edema, which is provoked by bradikinins and relieved by epinephrine agonists on alfa receptor (through vasoconstriction)..wild guess. 
good luck everybody
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| mjl1717
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alpha1-phenylephrine and methoxamine/////alpha 2 clonidine and methyldopa really have no use in asthma, if anything methoxamine's vagal effect may increase secretions!!
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| leen
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| vamsi2004
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its a typo.. shud be beta. the answer is Prostaglandin E (broncho and vasodilator)
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| docarchana
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yes its a typo. but i think the ans is leukotrienes
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