reet
Forum Fanatic
Topics: 152
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Three weeks after being bitten by a friend's puppy in Mexico, a 32-year-old man has tingling at the site of the bite followed by severe agitation and disorientation. The initial wound healed without complications. The puppy died 2 weeks ago. The route by which the infecting virus entered the brain is
A) blood-borne virions infecting cerebral capillary endothelial cells
B) blood-borne virions infecting choroid plexus cells
C) blood cells that cross the blood-brain barrier
D) transport within the axons into the central nervous system
E) virions carried by lymphatic drainage to the brain
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| Natasa
Forum Elite
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Posts: 291
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Its D.
Rabies virus first replicates at the site of the bite-within the muscle cells(and viral glycoproteins attach to nicotinic Ach receptors at nerve muscle junction).Then-when enough C exists-it comes into contact with sensory or motor nerve cells.Virus enters the axons at Ranvier nodes(where there is no myelin to block its entry) and moves up towards neron nuclei via retrograde axon transport via axoplasm and powered by dynein.So,it reaches spinal cord moving app.8-20 mm per day.
Interesting point:Oral herpes virus takes the same path(retrograde axonal transport).
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| Geroo
Forum Guru
Topics: 114
Posts: 799
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polio take the same path too
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| druas
Forum Elite
Topics: 47
Posts: 319
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definately D...rabies..retrograde axonal transport of the virus
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