DrVirgo
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Hi, please give your answer with a brief explanation. Thanks.
12. A 54-year-old woman with type 2 diabetes mellitus well controlled with oral hypoglycemic agents comes to the physician because of a 2-week history of swelling in her left knee. She tells the physician that her knee is very stiff when she awakens in the morning and at bedtime. The pain and stiffness worsen with exertion. Low-dose ibuprofen results in incomplete relief. Which of the following best explains why a larger dose of ibuprofen is more appropriate?
A) The anti-inflammatory dose is nearly twice the analgesic dose
B) The drug is excreted at a fast rate because of renal complications of diabetes mellitus
C) Increasing the dose extends the half-life of the drug
D) Menopausal women metabolize the drug at a faster rate than premenopausal women
E) Oral hypoglycemic agents interfere with protein binding of ibuprofen
26. A 37-year-old man develops a spiking fever in the intensive care unit after an operation to control an abdominal hemorrhage. Evaluation does not show a focal infection. Therapy with a broad-spectrum cephalosporin is initiated. After 3 days of antibiotic therapy, the patient has abdominal pain and profuse watery diarrhea. Examination of stool for ova and parasites is negative. Stool tests positive for Clostridium difficile antigen. The most appropriate therapy is
A) amphotericin
B) erythromycin
C) metronidazole
D) penicillin
E) trimethoprim-sulfamethoxazole
27. A 23-year-old woman has prolonged episodes of wheezing, dyspnea, and anxiety that are relieved by â-adrenergic agonists. The major mediator of her condition is
A) bradykinin
B) eosinophil chemotactic factors
C) leukotrienes
D) prostaglandin E
E) thromboxane
28. After several courses of treatment for non-Hodgkin's lymphoma, a 33-year-old man develops gross hematuria. Which of the following drugs is most likely to be responsible for this adverse effect?
A) Carmustine (BCNU)
B) Cyclophosphamide
C) Daunorubicin
D) Methotrexate
E) Vincristine
37. What is the principal site of therapeutic action of aspirin in the diagram of a blood vessel? a) b) c) d) e) f) g)
39. A 42-year-old man begins drug therapy for hypertension. Three months later, he has a chronic nonproductive cough. Findings on x-ray films of the chest are normal. He is most likely taking which of the following antihypertensive drugs?
A) Enalapril
B) Hydrochlorothiazide
C) Prazosin
D) Propranolol
E) Verapamil
31. A 50-year-old man with anginal pain takes nitroglycerin. The pain is rapidly relieved because of
A) inhibition of phospholipase C activity
B) stimulation of cyclic AMP formation
C) stimulation of cyclic GMP formation
D) Stimulation of inositol 1,4,5-trisphosphate formation
E) Stimulation of protein kinase C activity
39. A 42-year-old woman has dizziness and ringing in her ears 7 days after starting a drug. Which of the following drugs is the most likely cause?
A) Acetaminophen
B) Aspirin
C) Auranofin
D) Methotrexate
E) Prednisone
45. An 80-year-old woman comes to the physician because of a 2-week history of mild constipation and occasional inability to completely empty the bladder. She takes over-the-counter medications frequently. Vital signs are normal. Evaluation shows bladder distention and mild confusion. Which of the following drugs is the most likely cause of her symptoms?
A) Cimetidine
B) Diphenhydramine
C) Docusate sodium
D) Guaifenesin
E) Ibuprofen
3. A 2-year-old boy ingests an unknown quantity of iron sulfate tablets that his mother was given for anemia following childbirth. The most likely consequence of this ingestion is
A) Gastric bleeding
B) Metabolic alkalosis
C) Polycythemia
D) Respiratory depression
E) Urinary retention
4. A 56-year-old man who has colon cancer is being treated with 5-fluorouracil. Which of the following is the mechanism of the antineoplastic action of this drug?
A) Binding free dihydrofolate
B) Inhibiting carbamoyl phosphate synthetase I
C) Inhibiting ribonucleotide reductase activity
D) Inhibiting thymidylate synthetase activity
Answer: D)?
8. A 53-year-old woman comes to the clinic because of a 1-week history of pain and burning on urination. She is homeless and has a poor diet. The physician gives her enough trimethoprim-sulfamethoxazole to last 2 weeks. Because of her inadequate diet, she is at increased risk for which of the following adverse effects of this drug?
A) Cardiomyopathy
B) Megaloblastic anemia
C) Ototoxicity
D) Seizures
E) Systemic lupus erythematosus
13. An experimental drug is administered to a human subject with moderately severe congestive heart failure. Within minutes of intravenous administration, there is a measurable decrease in cardiac preload and cardiac afterload, and an increase in glomerular filtration rate. The effects of the drug are most similar to those produced by which of the following?
A) ADH (vasopressin)
B) Aldosterone
C) Angiotensin II
D) Atrial natriuretic peptide
E) Insulin
F) Norepinephrine
15. An obese 82-year-old woman with a 20-year history of type 2 diabetes mellitus has been taking glyburide orally for the past 5 years. Metformin is added to her regimen. Because she is taking metformin, she is at increased risk for which of the following?
A) Diabetic ketoacidosis
B) Lactic acidosis
C) Metabolic alkalosis
D) Renal tubular acidosis
E) Respiratory alkalosis
21. A 38-year-old woman undergoes surgical repair of a hip fracture. She has been treated for the past 20 years with high doses of inhaled and oral medications for severe asthma. During surgical repair, severe osteoporosis is noted. Long-term administration of which of the following drugs is most likely to have caused the osteoporosis?
A) Albuterol
B) Cromolyn sodium
C) Ipratropium
D) Prednisone
E) Theophylline
30. A 22-year-old college student who has been treated for anxiety and depressed mood for 6 weeks develops episodes in which she feels light-headed and almost faints. Pulse is 110/min, and blood pressure is 110/70 mm Hg while lying down and 85/60 mm Hg while standing. Which of the following drugs is most likely to have caused the orthostatic hypotension?
A) Alprazolam
B) Amitriptyline
C) Buspirone
D) Diazepam
E) Fluoxetine
33. The bar chart shows
The distribution of elimination half-life of theophylline for adults (solid) and children (striped). Which of the following characteristics of children best explains these data?
A) Hepatic metabolism is faster
B) Oral absorption is poorer
C) Renal secretion is lower
D) Theophylline is less potent
E) Volume of distribution is larger
34. A 55-year-old man is exposed to Malathion while working on a farm. After successful treatment of cholinergic symptoms with atropine, he continues to have difficulty breathing and muscle weakness. Which of the following is the most appropriate treatment?
A) Gallamine
B) Hexamethonium
C) Mecamylamine
D) Pilocarpine
E) Pralidoxime
37. A 60-year-old woman with osteoarthritis has recurrence of pain and stiffness in her joints. She is afebrile. The most appropriate therapy is
A) Allopurinol
B) Aspirin
C) Colchicine
D) Estrogen
E) Probenecid
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| anjushree
Forum Guru
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Posts: 386
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ANS---12)A
26)C
27)C
28)B
37)G
39)A
31)C
39)B
45)B
3)a
4)d
8)b
13)d
15)b
21)d
30)b
33)a
34)e
37)b
45)
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| Geroo
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39.is Acetaminophen or aspirin
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| rm
Forum Senior
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Posts: 77
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its Aspirin because with high doses salicylism can occur - vomiting, tinnitus, decreased hearing, vertigo
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| rm
Forum Senior
Topics: 16
Posts: 77
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3. A 2-year-old boy ingests an unknown quantity of iron sulfate tablets that his mother was given for anemia following childbirth. The most likely consequence of this ingestion is
A) Gastric bleeding
B) Metabolic alkalosis
C) Polycythemia
D) Respiratory depression
E) Urinary retention
Could someone explain the answer
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| skyhigh
Forum Guru
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Posts: 561
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isn't 30 b, amytriptiline has alpha blocking activity, so can cause orthostatic hypotension.
yes, that's right.
Edited by skyhigh on 02/08/06 - 07:38 PM
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| mjl1717
Forum Hero
Topics: 956
Posts: 5,452
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With 19 qs I cant give explanations (maybe a few later) 12)a, 26)c 27)c 28)b 37)diagram? 39)a 31)c 39)b 45)b 3)a 4)d 8)b 13)d 15)b 21)d 30)e 33)a 34)e 37)b
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| reet
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APSIRIN ---37 QUES... vessel lumen.. G)platelets,,neurtophils, monocytes,,H) endothelium,, smooth muscle?
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| mjl1717
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rm wrote:
3. A 2-year-old boy ingests an unknown quantity of iron sulfate tablets that his mother was given for anemia following childbirth. The most likely consequence of this ingestion is
A) Gastric bleeding
B) Metabolic alkalosis
C) Polycythemia
D) Respiratory depression
E) Urinary retention
Could someone explain the answer
iron causes Numerous effects eg. bloody diarrhea , coma, severe anion gap metabolic acidosi, renal insufficiency. liver failure, coagulation defects death etc.
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| druas
Forum Elite
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for the last question by mjl..i will go with A.... its an overdose of iron which is a common cause of poisoining in kids when they take adult iron formula,s as the kids iron prep..dose,nt have enough iron to cause poisoning.Within few initial hours of ingestion the first finding is a hemorrhagic gastroenteritis(most likely).Hepatic failure ,met.acidosis occurs late(around 2 to 3 days)and these options are not even on the list
anyone else on that??
Edited by druas on 02/08/06 - 10:52 PM
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| druas
Forum Elite
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4..ans is D..5FU causes thymine less death of cancer cells..
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| Natasa
Forum Elite
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I would also go with an A as gastric bleeding is most likely to happen right after the poisoning.latter on it could be hepatic failure,acidosis and other stuff.
4.It is D,for sure.Inhibition of thymidilate synthetase.
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| vamsi2004
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27 is D
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| tn1kinobe
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Question 8 about SMX-TMP.. it's megaloblastic anemia b/c she's low on folate from inadequate diet, which precipates the TMP (Treats Marrow Poorly) causing megaloblastic anemia.
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| Nan
Forum Senior
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Posts: 159
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27. A 23-year-old woman has prolonged episodes of wheezing, dyspnea, and anxiety that are relieved by â-adrenergic agonists. The major mediator of her condition is
A) bradykinin
B) eosinophil chemotactic factors
C) leukotrienes
D) prostaglandin E
E) thromboxane
Could anyone explain the answer? Thanks
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| ariane
Forum Newbie
Topics: 2
Posts: 17
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| fongch
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3 D refer to the following link
http://www.healthtouch.com/bin/EContent_HT/drugSh...
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| NJones
Forum Newbie
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Hey everybody, can you help me with this:
10. A 20-year-old woman develops severe pain and erythema over sun-exposed skin and large bullae over her shoulders while vacationing in Florida. Skin testing results in major positive reactions to methylparaben, which is often used as a preservative in medicines. A sunscreen containing which of the following is CONTRAINDICATED in this patient?<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
A) Avobenzone
B) Benzophenones
C) Cinnamates
D) p-Aminobenzoic acid esters
E) Salicylates
Please, send your answer and a brief explanation.
Thanks,
NJ
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| sattar
Forum Newbie
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the answer D. p.aminobenzoic acid esters
the explanation can be found in this link
http://dermnetnz.org/dermatitis/parabens-allergy....
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| werther
Forum Senior
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Posts: 110
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Hi guys! regarding the q about the kid taking the overdose of IRON. That question is including for the simple reason that iron overdose is the #1 toxicologic problem in kids under 6 yo.
I think the answer is A. All of the other just never happen.
Refer to this link:
http://www.emedicine.com/EMERG/topic285.htm
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