DrVirgo
Forum Hero
Topics: 1042
Posts: 3,343
|
3- 35 y/o M with Hx of sever PUD has been diagnosed/w prolactinoma. There is family Hx of pituitary tumors. Which of the ffg diagnostic tests maybe abnormal & can help in Dx?
A- FBS
B- Serum Ca
C- Serum calcitonin
D- Urinary metanephrin
E- Serum ferritin
F- Thyroid function tests
Please explain.
thanks.
___________________
Our greatest glory is not in never falling, but in rising every time we fall.
|
| Natasa
Forum Elite
Topics: 9
Posts: 291
|
FIGURE 1. Physiology of lactation.
Information from references 2 through 4.
I guess it's the thyroid function tests-Due to negative feedback from prolactin on hypotalamo-pituitary axis and hence decrease in TRH from hypothalamus.
|
| Natasa
Forum Elite
Topics: 9
Posts: 291
|
It didn't paste the figure:Anyways what it says is that there is a stimulation of prolactin secretion by hypothalamic TRH and that when you have prolactinoma,there is a negative feedback and hence decrease in thyroid hormones.
|
| reet
Forum Fanatic
Topics: 152
Posts: 1,411
|
HISTORY of pitutary tumor + PUD ( is it MEN 2b??)
C.. serum CALCITONIN ---- in medullary carcinoma OF thyroid
___________________
Live as u were to die tommorow. Learn as if u were to live forever.
|
| Natasa
Forum Elite
Topics: 9
Posts: 291
|
Sorry,I am an idiot:What is sever PUD i the question above?(missed that...)
|
| druas
Forum Elite
Topics: 47
Posts: 319
|
Dont worry natasa...reet also did,nt go thru it well...hey reet...why menIIb???..he dosent have pheochromocytoma and neuromas...Its is MEN type 1.so only thing missing is parathyroid malignancy..so ans should be ..B(remember 3p,s of MEN 1).
MEN TYPE 1...(wermer synd)Pituitary,pancreatic and parathyroid
MEN TYPE 2...(sipple synd) parathyroid,pheochromocytoma,medullary ca.of thyroid)
MEN TYPE 2b..medullar ca,pheochromocytoma and mucosal neuroma..
Am i right
|
| reet
Forum Fanatic
Topics: 152
Posts: 1,411
|
hahahhahah druas. u caught me... thank GOD it wasnt my real exam.. i will have to be careful now.
well,, how come PROLACTINOMA???
___________________
Live as u were to die tommorow. Learn as if u were to live forever.
|
| DrVirgo
Forum Hero
Topics: 1042
Posts: 3,343
|
Answer is B- serum Ca.
I agree it has to be MEN I
MEN TYPE 1...Pituitary,pancreatic and parathyroid AND Peptic ulcers... thats how i remember it. (all the P's)
___________________
Our greatest glory is not in never falling, but in rising every time we fall.
|
| skyhigh
Forum Guru
Topics: 105
Posts: 561
|
WHAT DOES "PUD" STAND FOR?
|
| Natasa
Forum Elite
Topics: 9
Posts: 291
|
Exactly my point here skyhigh.
ANYONE?
|
| druas
Forum Elite
Topics: 47
Posts: 319
|
peptic ulcer disease...(PUD)
|
| reet
Forum Fanatic
Topics: 152
Posts: 1,411
|
wht about PROLACTINOMA??? is it in MEN1?
___________________
Live as u were to die tommorow. Learn as if u were to live forever.
|
| DrVirgo
Forum Hero
Topics: 1042
Posts: 3,343
|
Yes, Prolactinoma can be in MEN I because MEN I includes Pituitary Adenomas.
Prolactin is from Ant. Pituitary.
It can also secrete increased GH.
So to review:
MEN I: 4P's:
1. Pituitary Adenoma: GH or Prolactin
2. Parathyroid: Hyperplasia or Adenomas
3. Pancreas: Adenoma, Islet cell tumor: beta cells secrete Insulin (insulinoma) and grastrinomaWhich can lead to ZE syndrome (increase gastrin causes increased acid in stomach and thus:
4. Peptic Ulcers (which is a complication of the above tumor)
MEN I is related to MEN I gene
___________________
Our greatest glory is not in never falling, but in rising every time we fall.
|
| doc179
Forum Guru
Topics: 67
Posts: 1,217
|
good Q
|
|
| |
| | | | | | | | | | | | | | |
