reet
Forum Fanatic
Topics: 152
Posts: 1,411
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a 3 yo boy has a mutation in the calcium receptors on cell surfaces of his parathyroid gland and on the basolateral (blood) side of the thick ascending limb of the loop of henle. Which of the following patterns is expected with a mutation that leads to activation of this receptor in the absence of binding of itss ligand, calcium?
Ca2+ PTH Urine Ca
a. Hyper-Ca Hi Hi
b. Hyper- Ca Hi Lo
c. Hyper-Ca Lo Hi
d. Hyper-Ca Lo Lo
e. Hypo-Ca Hi Hi
f. Hypo-Ca Hi Lo
g. Hypo-Ca Lo Hi
h. Hypo-Ca Lo Lo
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| drk1980
Forum Guru
Topics: 147
Posts: 1,038
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the answer to this is supposedly...G
the receptor mutation on the parathyroid gland causes it to sense Ca++ to be present in the blood inspite of low levels.......so PTH wont be secreted...and Ca levels keeps falling.....bcoz of the hypoparathyroidism brot on by this mutation...thr is nothing to reabsorb Ca from the urine(DT)...therefore higher urine levels...
is ths wht ws gvn?
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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u mean f, if urine ca is high, and serum ca low
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| skyhigh
Forum Guru
Topics: 105
Posts: 561
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wouldnt this be A
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| Geroo
Forum Guru
Topics: 114
Posts: 799
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agree with drk
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