reet
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can anyone explain,,,, renal system PHYSIO in diabetes .
wht happen to WATER,,GLUCOSE SODIUM....electrolytes...??? reabsorptption/sectretions????
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| msyamp
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hi reet. i will try to explain a bit here.
there is actually lots to know about diabetes and kidney as it has different effects in different stages of the disease.
basically it causes glycouria and due to that it takes water along with that causing osmotic diuresis. this will the first effect.
now diabetes keeps body in an acidotic margin of the Ph and hyperkalemia. there will be conservation and reabsorbtion of bicarbonate and ecretion of H+.the peculiar thing here is there is actually a lack of total body potassium due to urinary losses. so in treatment monitoring blood potassium levels is important. as we give insulin and glcose and hydrate him. all the K that has leaked out of the cells get into its home cells and leaves hypokalemia so supplement K too. i am sorry for side tracking.
After sometime when the cells in the renal tubules had taken years reabsorbing some amounts of the sugar in urine all the proteins in the cells will be glycosylated and cells some time fall of as casts or sugar crystals then all theregulations of kidney is effected. no reabsorbtion and all regulations are disturbed. graduatlly hyline deposits in glomeruli. all leading to WK syndrome and ESRD.
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| reet
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THANKS........
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| mildus
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Very nice explanation,msyamp!
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| skyhigh
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i forget, what is ESRD? thanks
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| reet
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skyhigh,,, is it END STAGE RENAL DISEASE????
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| msyamp
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hey reet. its end stage renal disease sometimes equals chronic renal failuer
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| coolmavs
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Guys I am asking a question based on Glucose causing osmotic diuresis. all agents causing osmotic diuresis (including mannitol and Hyperglycemia) act on the PCT n are assoc. with increase excretion of Na leading to Hyponatremia. Then why is that in DM, GFR is said to be increased assoc with decreased Na delivery to the macula densa?
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