DrVirgo
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Two individuals become infected with HIV at the same time. Patient 1 progresses rapidly to full blown AIDS and dies within 3 years. Patient 2 is still asymptomatic after 10 years. One possible explanation is that the virus in Patient 1 is probably expressing a high amount of activity of which regulatory gene product?
A. vif
B. vpr
C. tat
D. env
E. pol
(Please explain your answer, and you you think the others are wrong!)
Thanks.
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| reet
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I THINK C . tat
tat--regulatory protein
vif,vpr- accessory proteins
env,pol--structural proteins
Edited by reet on 02/02/06 - 11:13 PM
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| Geroo
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agreed
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| Geroo
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I don't know what is the function of vif and vpr.any idea?
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| DrVirgo
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Yes, its C. tat.
-pol codes for RT, integrase and protease
-env codes for gp120 and gp41
-tat and rev upregulate transcription. They increase viral maturation and act to decrease the latent period.
-vif affects viral infectivity.
-vpr increases efficiency of budding
-nef is confusing:
in Kaplan micro section they say:
"multiple functions, one of which is to decrease MHCI on infected T-Cells. it's gene product is Negative Factor.".. It also says: "Initially thought to downregulate HIV production; now thought to enhance the pathogenicity of HIV."
Then Kaplan same Micro book... viral questions explanation to this q says: "supresses transcription of viral DNA and tends to keep the infection in a latent state"
Can anyone please clarify this?
Also, why is the answer not pol?!
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| Ashley84
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nef is an early gene in HIV replication. It affects signaling tradsuction in cells and decreases the exocitic pathway, reducing the number of CD4 and MHCI in membrane.
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