drk1980
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High altitude is known to cause a left shift of the Hb-O2 curve. One reason being an inc in 2,3BPG levels due to an inc in rate of glycolysis.
What is the triggering factor in these high altitude conditions for increasing the rate of glycolysis?
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| skyhigh
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actually it is easy for tissues to extract oxygen given right shift of 2-3 bpg curve.
b/c there is less affinity of O2 to hemoglobin, (dec P02), i think the velocity of glycolysis increases, i.e; decreased Km and increased Vmax.
Edited by skyhigh on 02/02/06 - 03:38 PM
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| reet
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left shift not due to increase 23 BPG... ITS DUE TO DECREASE 2,3 BPG???
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| skyhigh
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yes, dec 2,3BPG in left shift
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| drk1980
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oops! sorry abt tht.... momentary left-right disorientation. 
i meant to say "right shift of curve" in high altitude.
i agree wth u on hypoxia causing an inc in glycolytic rate via an inc cardiac output(inc HR) and inc ventilatory rate....right?
is tht all though?
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| Geroo
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i think that's all,also hypoxia leads to increase erythopoiten and increase htc
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| sturge_weber
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,well yes its hypoxia which drives glycolysis and then the 23 bpg is formed which shifts the curve to the right and hence delivery of o2 to the tissues becomes easier....
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| sturge_weber
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now think of this and answer this one, we hyperventilate at high altitudes, so the curve should shoift to the left, so what happens the shift to the left or to the right
will give u the ans....
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| Geroo
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the cure will shift to the right I think that the increase 2,3 Bbg
will have the greatest effect on the curve ,also the ph will return return to normal as the kidney will dumb more hco3 in urine that's will let the curve not to left shift,that's my assumption
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| sturge_weber
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thats what i read, that the hyperventilation will try to shift the curve to the left, but inc in 23bpg will shift the curve to the right, but 23bpg increases finally tkaes the balance of shifting the curve to the right....
yes and the hco3 point also is right
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| reet
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GOOD POINT. .. sturge and GEROO
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| Doc2378
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Good discussion there guys...
to add to the confusion...does an increase in EPO play any role in shifting the curve at all? Which one's more important at high altitude: EPO versus 2,3 BPG??
...if you know why I am asking you guys to discuss this concept too!
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| reet
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at high altitude (left shift curve )is stimulation to EPO releases( due to hypoxemia) and EPO increases erythropoiesis ( polcythemia can occur)----furtherpolycythemia is suppresor of EPO release.
AS 2BPG also increase thru glycolsis (due to hypoxia). >>>>rt shift...I THINK THIS IS MORE IMPORTANT..
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| Doc2378
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...that sounds correct to me Reet!
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| rouadefoc
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Thank you for clearing this subiect for me too, even later.
Good luck.
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