usmlebuzz
Forum Elite
Topics: 93
Posts: 263
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The Coronary Drug Project was
a randomized trial to evaluate the
efficacy of several lipid-lowering
drugs. The five-year mortality of the
men who adhered to the regimen of
clofibrate (i.e., took 80% of their
medicine or more) was 15%; among
those assigned to the clofibrate
group who were less compliant, it
was 24.6%. The result was highly
statistically significant (p < 0.0001).
From this one can conclude
a. Clofibrate was very beneficial to the
patients who took it reliably
b. Clofibrate is not effective unless
patients take at least 80% of the
recommended doses
c. Either clofibrate or something associated
with taking it reliably is
strongly associated with reduced
total mortality
d. There was a problem with blinding
in this study
e. Only those who were compliant
should be included in the data
e. A correlation study with a small
number of countries
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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i think A is correct
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| meg
Forum Guru
Topics: 62
Posts: 806
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c?
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| mjl1717
Forum Hero
Topics: 958
Posts: 5,463
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d- a problem with blinding
___________________
Smell the coffee! "Is That an Osler move??"
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| sunny
Forum Junior
Topics: 4
Posts: 43
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From data, answer ought to be C
___________________
Gurvinder Singh
India.
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| dfsa
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has to be A because the statistical sig (p > 0.0001), meaning that the result is 99.999% accurate.
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| sunny
Forum Junior
Topics: 4
Posts: 43
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Waiting to hear Ritu's opinion.......... :|
___________________
Gurvinder Singh
India.
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Intent-to-treat analysis, that is including in the final results all the subjects
who were initially randomized to receive either the drug or the placebo, is
the preferred method of analysis for intervention studies. Although it may
be tempting to include only those who complied with the medication, the
results can be misleading. This study is a classic example of this pittfall.
Indeed, the study showed that the difference in mortality between those
who did and did not adhere to placebo was even greater: 15 versus 28%.
The difference persisted even after controlling for 40 different confounders.
Thus, something related to compliance (with either the medication or the
placebo) appeared to decrease mortality. Therefore, as a rule, remember
that once randomization has been performed, all participants, regardless of
their compliance, should be included in the results.................
so C is correct
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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I agree. Cant pigeonhole yourself too much on these. It should be c. It can be helpful to always look for the least specific answer that is still correct. (i always do that as a starter on these).
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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I should follow this up. One could assume that those individuals taking their meds would also be making lifestyle modification intended to benefit their condition. Those individuals not taking their meds might be more prone to not exercise such control (exercise, diet, etc.)
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