drk1980
Forum Guru
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What is the main host defense against bacterial exotoxin?
A) Activated macrophages secreting protease
B) IgG and IgM Antibodies
C) Helper T cells
D) Modulation of host cell receptors in response to the toxin
plz explain!
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| skyhigh
Forum Guru
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i think B b/c it is defense against extracellular organism involves antibodies, complements and phagocytosis
defense against intracellular organisms involves DTH, CD8+ cytotoxic cells, NK cells, ADCC cells and activated macrophages.
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| mildus
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I agree with skyhigh, that is why serum (with antitetanus antibodies) is given to people when they are infected by Clostridium tetani
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| drk1980
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Topics: 147
Posts: 1,038
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thanks u two!
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| drk1980
Forum Guru
Topics: 147
Posts: 1,038
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just wanted to clarify, would it be the same for an endotoxin?
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| mildus
Forum Guru
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Endotoxin is a part of LPS. It is placed deep in the outer membrane so it doesn't make any problems because it is not on the surface. It only makes problems when bacteria die, because that is when endotoxin is released into the blood. The most dangerous is when much of it is released at the same time, as it can cause sepsis, septic shock, disseminated intravascular coagulation.
I don't know if antibodies have something to do here, because it is important to be very quick and we don't have time to wait for antibody production. I would rather say that phagocytosis is the main way of destroying it.
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